Searchable abstracts of presentations at key conferences on calcified tissues

ba0005cabs.oc2.1 | Oral Communications | ECTS2016

Prostate cancer microRNAs in extracellular vesicles stimulate osteoclastogenesis

Bijnsdorp Irene , Mulder Jorn , Geldof Albert , Bakker Astrid , de Vries Teun , van Moorselaar Jeroen

Prostate cancer (PCa) is the most common cancer in males. When patients develop metastasis, no curative therapy is available. To find new therapeutic options, it is crucial to understand how PCa cells induce metastasis. Recently, it was shown that PCa cells secrete small extracellular vesicles (EVs) that can be found in the circulation and in bones. Uptake of EVs by other cells may change their behaviour. We previously identified three miRNAs that were uniquely upregulated in ...